Glycyrrhizin & Cancer

"Glycyrrhizin is a plant glycoside extracted from roots of the liquorice plant."
https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/glycyrrhizin

"glycyrrhizin was found to significantly inhibit the growth of lung cancer cells in vitro and tissues in mice. However, the detailed inhibitory role of glycyrrhizin in the growth of lung cancer is still unclear."
https://www.hindawi.com/journals/bmri/2018/6916797/

"GL showed protection and detoxication by decreasing reactive oxygen species generation, maintaining GSH and differentially modulating apoptosis, AKT pathway, ERK and JNK of MAPK pathway. Collectively, our results demonstrate that GA, instead of GL, is a better candidate for TNBC treatment because of its anti-cancer effect and sensitization of topoisomerase IIα inhibitor."
https://pubmed.ncbi.nlm.nih.gov/28506909/

The role of Glycyrrhizin, an inhibitor of HMGB1 protein, in anticancer therapy
https://pubmed.ncbi.nlm.nih.gov/22922889/

Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1
https://www.mdpi.com/2072-6694/13/13/3265

Glycyrrhizin induces apoptosis in human stomach cancer KATO III and human promyelotic leukemia HL-60 cells
https://pubmed.ncbi.nlm.nih.gov/16012754/

Glycyrrhizic Acid Inhibits Proliferation of Gastric Cancer Cells by Inducing Cell Cycle Arrest and Apoptosis
https://www.dovepress.com/glycyrrhizic-acid-inhibits-proliferation-of-gastric-cancer-cells-by-in-peer-reviewed-fulltext-article-CMAR