Could a specific mixture / formula created from these ingredients treat, cure or prevent SARS-CoV-2 / COVID-19 and / or any other type viruses?

in #medical3 years ago (edited)

"There were a few studies providing direct evidence on associations between zinc, selenium, and vitamin D, and COVID-19. Adequate supply of zinc, selenium, and vitamin D is essential for resistance to other viral infections, immune function, and reduced inflammation. Hence, it is suggested that nutrition intervention securing an adequate status might protect against the novel coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome - coronavirus-2) and mitigate the course of COVID-19.

Conclusion: We recommended initiation of adequate supplementation in high-risk areas and/or soon after the time of suspected infection with SARS-CoV-2."
https://pubmed.ncbi.nlm.nih.gov/32784601/

"Nonetheless, it is common practice to recommend a ratio of 8-15 mg of zinc for every 1 mg of copper consumed. However, this ratio seems to be more important when supplementing zinc and copper, compared to meeting needs through diet alone (7)."
https://susanmacfarlanenutrition.com/understanding-nutrient-ratios-zinccopper/

"Vitamins (A, B, C, D, and E), minerals (selenium and zinc), and bioactive substances from curcumin, echinacea, propolis, garlic, soybean, green tea, and other polyphenols were identified as having potential roles in interfering with spike glycoproteins, angiotensin converting enzyme 2, and transmembrane protease serine 2 at the entry site, and inhibiting activities of papain-like protease, 3 chymotrypsin-like protease, and RNA-dependent RNA polymerase in the replication cycle of severe acute respiratory syndrome coronavirus 2."
https://www.sciencedirect.com/science/article/pii/S0899900720303865

Colloidal Zinc

"Zinc promotes immune functions and helps people resist infectious diseases"
https://www.cdc.gov/nutrition/micronutrient-malnutrition/micronutrients/index.html

"The optimal dose of zinc for the treatment of COVID-19 is not established. The recommended dietary allowance for elemental zinc is 11 mg daily for men and 8 mg for nonpregnant women.5 The doses used in registered clinical trials for COVID-19 vary between studies, with a maximum dose of zinc sulfate 220 mg (50 mg of elemental zinc) twice daily."
https://www.covid19treatmentguidelines.nih.gov/adjunctive-therapy/zinc/

"Medical researchers from the Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, in the Netherlands explain that the replication of all these viruses can be stopped when zinc concentrations force a correction of proteolytic processing of viral polyproteins."
https://www.naturalmedicine.news/2020-06-10-zinc-effective-treatment-for-coronavirus-infection-blocks-viral-replication.html

Colloidal Copper

"If instead of stealing useful metals like zinc, Johnson could deliver toxic copper to the virus’s spike proteins, it could be rendered inoperable."
https://research.arizona.edu/stories/could-copper-disable-virus-behind-covid-19

"Most importantly, the ions seek and destroy the DNA and RNA inside a bacteria or virus, preventing the mutations that create drug-resistant superbugs. “The properties never wear off, even if it tarnishes,” Schmidt says."
https://www.smithsonianmag.com/science-nature/copper-virus-kill-180974655/

Colloidal Silver

"Silver nanoparticles are broad-spectrum bactericidal and virucidal compounds"
https://pubmed.ncbi.nlm.nih.gov/21812950/

Magnesium

"Vitamin D and magnesium (Mg) are some of the most studied topics in medicine with enormous implications for human health and disease. Majority of the adults are deficient in both vitamin D and magnesium but continue to go unrecognized by many health care professionals.

Areas of uncertainty: Mg and vitamin D are used by all the organs in the body, and their deficiency states may lead to several chronic medical conditions"
https://pubmed.ncbi.nlm.nih.gov/28471760/

"Magnesium and vitamin D are 2 essential nutrients that are necessary for the physiologic functions of various organs. Magnesium assists in the activation of vitamin D"
https://jaoa.org/article.aspx?articleid=2673882

Calcium

"Where does calcium come in to all of this? Right at the beginning.

“The cell maintains a concentration gradient of calcium ions (Ca+2) of 10,000 to 1 across its membrane,” Helland said. “This gradient causes a strong (in the microscopic world) electromagnetic force around the cell. When this concentration gradient is maintained, it is very difficult for the virus to break into the cell. If anything disrupts this crucial balance, viruses can break in easily.”

If the virus has a difficult time breaking into a cell, it can’t replicate as easily, and the body has more time to develop antibodies against the virus before its numbers become overwhelming.

After the cell membrane, another calcium ion barrier protects the nucleus in the Endoplasmic Reticulum, where DNA and RNA from the nucleus are translated into proteins.

“If that gradient is well maintained, the virus again has a difficult time breaking in,” Helland said."

"“Vitamin D, at higher doses, has the tendency to steal the much needed calcium ions away from the cell walls making it easier for viruses to infect the cells,” Helland said."
https://www.chaffeecountytimes.com/free_content/calcium-ions-protect-from-the-common-cold-to-covid-19/article_aad1c106-6ec5-11ea-a472-1f41b486bc27.html

"Calcium is vital in the functioning of our immune system. Depletion of tissue calcium not only leads to increased virus and bacterial infections, but can be a general indicator of susceptibility to severe illness with higher mortality rate"
https://lakewoodacupuncture.org/2020/04/20/calcium-immunity/

Iodine

"Iodine kills all single-celled organisms and viruses. They can never become resistant to it."
http://drkentshow.com/wordpress/?tag=iodine-kills-viruses

EGCG

"Studies have shown that GTCs, especially epigallocatechin-3-gallate (EGCG), have antiviral effects against diverse viruses"
https://pubmed.ncbi.nlm.nih.gov/28805687/

"The EGCG can latch on to the zinc ion and carry it into the cell cytoplasm, where the zinc inhibits a viral protein called replicase. Replicase (or RdRp) makes copies of viral RNA. Both SARS-CoV-1 and SARS-CoV-2 have a replicase protein. The replicase protein complex (made up of several proteins) is blocked by zinc ions, preventing the virus from making copies of its RNA. This stops the virus from multiplying.

Further research on SARS-CoV-1 and SARS-CoV-2 and GTE found that EGCG (epigallocatechin gallate) and other Catechins are able to inhibit the virus directly, even without zinc"
https://covid.us.org/2020/09/30/covid-19-and-green-tea-extract-egcg/

Quercetin

"Quercetin is a zinc ionophore. And research indeed shows quercetin fights viral infections.

Dr. Seheult cites a study published in the journal Viruses. It shows that quercetin inhibits “a wide spectrum” of flu strains and blocks infection.[vii]

Of course, the flu is not coronavirus. But quercetin is about to be tested against the new disease."
https://www.institutefornaturalhealing.com/2020/03/coronavirus-early-research-provides-hope-that-one-supplement-could-help-control-it/

"Quercetin was initially found to provide broad-spectrum protection against SARS coronavirus in the aftermath of the SARS epidemic that broke out across 26 countries in 2003.1,2,3 Now, some doctors are advocating its use against SARS-CoV-2, in combination with vitamin C, noting that the two have synergistic effects.

Incidentally, ascorbic acid (vitamin C) and the bioflavonoid quercetin (originally labeled vitamin P) were both discovered by the same scientist — Nobel prize winner Albert Szent-Györgyi.4,5 Quercetin’s antiviral capacity has been attributed to five main mechanisms of action:

Inhibiting the virus’ ability to infect cells by transporting zinc across cellular membranes
Inhibiting replication of already infected cells
Reducing infected cells’ resistance to treatment with antiviral medication
Inhibiting platelet aggregation — and many COVID-19 patients suffer abnormal blood clotting
Promoting SIRT2, thereby inhibiting the NLRP3 inflammasome assembly involved with COVID-19 infection"

https://www.lewrockwell.com/2020/08/joseph-mercola/quercetin-and-vitamin-c-synergistic-therapy-for-covid-19/

Medium-chain saturated and long-chain unsaturated fatty acids & Monoglycerides

"Oleic acid (18:1) and palmitoleic acid (16:1) were potent inactivators of the virus"
https://pubmed.ncbi.nlm.nih.gov/921248/

"Medium-chain saturated and long-chain unsaturated fatty acids, on the other hand, were all highly active against the enveloped viruses, although the fatty acid concentration required for maximum viral inactivation varied by as much as 20-fold. Monoglycerides of these fatty acids were also highly antiviral, in some instances at a concentration 10 times lower than that of the free fatty acids. None of the fatty acids inactivated poliovirus. Antiviral fatty acids were found to affect the viral envelope, causing leakage and at higher concentrations, a complete disintegration of the envelope and the viral particles."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174645/

Monolaurin

"It actually can make the fatty envelope of a pathogenic organism like a virus soluble, thereby disintegrating its outer membrane and ultimately killing off the virus and preventing replication."
https://draxe.com/nutrition/monolaurin/

"Monolaurin might be active against viruses that have a fat (lipid) membrane on the outside. Since monolaurin is the same size as the fat molecule of the virus, it absorbs into the cell’s fat layer. Since it does not have good binding power, the skin envelope breaks apart. This prevents the virus from attaching and entering host cells, stopping infection and replication. Have in mind that this is still just an unproven theory based on cellular studies [1, 2].

Scientists think monolaurin might disrupt virus replication by blocking DNA replication signals. In the lab, when monolaurin binds to the viral envelope, it makes the virus more susceptible to the immune system [3, 4]."
https://selfhacked.com/blog/can-monolaurin-fight-coronavirus-covid-19/

Alpha-Lipoic Acid

"A study in Wuhan, China, found critically ill Covid-19 patients given ALA fared better than those given a placebo, but due to how few people were in the study (just 17) it concluded there was only a “borderline statistical difference” between the two groups."
https://fullfact.org/health/coronavirus-cures-debunked/

"Alpha-lipoic acid is an effective inhibitor of human immuno-deficiency virus (HIV-1) replication"
https://pubmed.ncbi.nlm.nih.gov/1724477/

Vitamin A, B, C, D, E

"Recent clinical trials suggest that vitamin A supplementation reduces morbidity and mortality in different infectious diseases"
https://pubmed.ncbi.nlm.nih.gov/10604208/

“Vitamin B not only helps to build and maintain a healthy immune system, but it could potentially prevent or reduce COVID-19 symptoms or treat SARS-CoV-2 infection,” they write. “Poor nutritional status predisposes people to infections more easily; therefore, a balanced diet is necessary for immuno-competence.”
https://www.yahoo.com/lifestyle/vitamin-b-could-help-prevent-the-worst-outcomes-in-covid-19-cases-experts-say-163709320.html

"so if people want to take a gram or so of vitamin C, that would be fine."

There's a large body of research supporting Fauci's recommendations. Studies suggest vitamin D and C are your best bet for supplementing immune health"
https://www.msn.com/en-us/health/nutrition/dr-fauci-says-he-takes-vitamin-d-and-c-supplements-and-that-they-can-lessen-your-susceptibility-to-infection/ar-BB18WvmA

"The preventive effect of vitamin E was stronger than the effect of vitamin C, but the combination (vitamin E + C) had the strongest effect. The superior protective effect of the combination is probably due to vitamin C's repairing effect on vitamin E's tocopheroxyl radical."
https://pubmed.ncbi.nlm.nih.gov/12808470/

Selenium

"Selenium is particularly important for your ability to fight off viruses.

When humans and mice have enough selenium, viruses appear to replicate slower."
https://www.clearvuehealth.com/d/selenium-virus/

"Selenium is an essential dietary trace element that over the last 40 years has been found to be a significant factor affecting the incidence, severity, or mortality of various viral diseases, in animals and humans"
https://news.uncg.edu/research-link-covid-19-selenium/

"There are many studies showing that selenium deficiency lowers immune function, and that selenium supplementation increases immune function."
https://www.cihs.edu/single-post/2020/03/20/COVID-19-Prevention-and-Treatment

Probiotics

"Works collected in this review show a beneficial effect of probiotics in the prevention and treatment of different viral infections. We found interesting results related to the prevention of viral infections, reduction of the duration of diseases, and decrease of symptoms."
https://www.docwirenews.com/abstracts/probiotic-effects-against-virus-infections-new-weapons-for-an-old-war/

"Scientists have discovered that a specific blend of probiotics can be effective at preventing flu, colds, and other respiratory infections.

In one study, this probiotic blend reduced the number of flu and flu-like respiratory illnesses by 75% and colds by 39% compared to a placebo.4

When flu and colds did occur, this same probiotic blend reduced duration and severity.4"
https://www.lifeextension.com/magazine/2019/12/probiotic-protection-against-flu-and-cold-viruses

Proteolytic Enzymes (Bromelain, Papain)

"The first of proteolytic enzymes’ many talents is their ability to “eat up” the protective coating on a virus.

  1. Systemic proteolytic enzymes eat up virus’ protective coating

The outer protein coating on a virus, called the capsid, protects the virus and helps it to attach to a host cell and multiply. This protective coating is part of what makes viruses so difficult to eliminate from your body.

Viruses also have protein spikes that extend from their outer layer. These spikes help the virus infect new cells and contact surfaces.

Research shows bromelain, a type of systemic enzyme found in pineapples, has a cleaving effect on both of these parts of some viruses1.

But not only do proteolytic enzymes rid a virus of its protective outer coating. They also support your immune system, helping it to further rid your body of viruses, for an effective two-pronged virus-busting attack."
https://losethebackpain.com/fight-viruses-with-enzymes/

"Enzymes, particularly the proteases, turn out to be an excellent therapy to use against a virus, working on several levels. Many viruses are surrounded by a protective protein film, something a protease enzyme can digest away. Eliminating this coating leaves the viruses unprotected and vulnerable to antivirals and destruction."
http://www.enzymestuff.com/conditionviruses.htm

Glutathione

"Dr. Murray makes the profound statement: “The bottom line is that if you want to survive this pandemic, you need to take steps to boost your glutathione stores and definitely avoid drugs like acetaminophen that can cause glutathione levels to plummet.”"
https://naturesoutlet.net/drmurrayglutathione/

"“When you get a viral infection with a huge amount of inflammation you don’t have enough glutathione to be able to protect your very sensitive lung tissue,” Horowitz said.

James did not hesitate to give his mom the nutritional supplement, which they had in the house for Julia. After one 2,000-milligram dose, the family witnessed a miracle.

“Within an hour my breathing got better. It was amazing. I sat up, I got up,” Josephine Bruzzese recalled"
https://nypost.com/2020/05/09/new-york-mom-with-coronavirus-saved-by-medical-student-son/

"Lab studies showed that adding glutathione can reduce HIV-1 viral replication by over 99%! This may well apply to other viral infections, including coronaviruses.

Some studies showed that oxidative stress (having excess free radicals) in the host can cause infecting viruses to become more virulent! Glutathione is crucial because it is the most important antioxidant for our cells to overcome oxidative stress."
https://maxhealthsolution.com/2020/02/29/coronavirus-how-glutathione-cellgevity-may-help-to-protect-you/

""I have found glutathione deficiency in nearly all very ill patients." Doctor Mark Hyman MD"
http://healthyprotocols.com/2_glut.htm

"Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients"
https://pubmed.ncbi.nlm.nih.gov/32463221/

N-acetylcysteine

"There has been a great deal of talk about N-acetylcysteine and its importance in boosting cellular immunity, inhibiting virus replication, and supporting immune function."
https://vagusnervesupport.com/before-taking-n-acetylcysteine-read-this/

"The antioxidant N-acetyl-L-cysteine (NAC) had been shown to inhibit replication of seasonal human influenza A viruses."
https://pubmed.ncbi.nlm.nih.gov/19732754/

"The study researchers think that a medication called N-acetylcysteine can help fight the COVID-19 virus by boosting a type of cell in your immune system that attacks infections. By helping your immune system fight the virus, the researchers think that the infection will get better, which could allow the patient to be moved out of the critical care unit or go off a ventilator, or prevent them from moving into a critical care unit or going on a ventilator"
https://clinicaltrials.gov/ct2/show/NCT04374461

Curcumin

"The turmeric compound curcumin has been found to inhibit a number of significant viruses, including zika virus, hepatitis, herpes, chikungunya virus, influenza-A, HIV and HPV."
https://www.insiderlife.com/health/curcumin-from-turmeric-inhibits-zika-hiv-herpes-and-other-viruses/

"This study demonstrates a novel mechanism by which curcumin inhibits the infectivity of enveloped viruses. In all analyzed enveloped viruses, including the influenza virus, curcumin inhibited plaque formation. In contrast, the nonenveloped enterovirus 71 remained unaffected by curcumin treatment. We evaluated the effects of curcumin on the membrane structure using fluorescent dye (sulforhodamine B; SRB)-containing liposomes that mimic the viral envelope. Curcumin treatment induced the leakage of SRB from these liposomes and the addition of the influenza virus reduced the leakage, indicating that curcumin disrupts the integrity of the membranes of viral envelopes and of liposomes"
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062482

Oregano Oil

"Although there are no direct links to oregano oil being effective against COVID-19, it has exhibited strong antiviral activity against several nonenveloped RNA, and DNA viruses such as adenovirus type 3, poliovirus, and coxsackievirus B1.179"
https://www.burrisinstitute.com/blogs/covid-19-and-oregano-oil-what-does-science-say

"Oregano essential oil has long been known for its health-promoting benefits. Here, we report its activity against viral replication. Oregano oil was found to specifically inhibit lentiviruses, such as human and simian immunodeficiency viruses (HIV and SIV), irrespective of virus tropism, but not hepatitis C virus, adenovirus 5 (ADV5), Zika virus, and influenza (H1N1) virus. Oregano oil's most abundant components, carvacrol and its isomer, thymol, were shown to block virus-target cell fusion while not perturbing other stages of the virus life cycle"
https://pubmed.ncbi.nlm.nih.gov/32461309/

Astragalus

"As reported, astragalus polysaccharides (APS) have potential antiviral effects against several viruses; however, the antiviral effect of APS against IBV remains unclear."
https://pubmed.ncbi.nlm.nih.gov/29170045/

"One study revealed that astragalus root is effective at inhibiting the herpes simplex virus type 1 (HSV-1), while another showed that it inhibits RNA replication in some virus strains (8, 9)."
https://blog.paleohacks.com/antiviral-herbs/

Echinacea

"These results indicate that E. purpurea has the potential to reduce the risk of respiratory complications by preventing virus-induced bacterial adhesion and through the inhibition of inflammation super-stimulation (cytokine storms)."
https://pubmed.ncbi.nlm.nih.gov/28279802/

"Echinacea inhibited virally confirmed colds and especially prevented enveloped virus infections ( 𝑃 < 0 . 0 5 ). Echinacea showed maximal effects on recurrent infections, and preventive effects increased with therapy compliance and adherence to the protocol. Conclusions. Compliant prophylactic intake of E. purpurea over a 4-month period appeared to provide a positive risk to benefit ratio."
https://www.hindawi.com/journals/ecam/2012/841315/?fbclid=IwAR2K29pZiPjwn5zcmD7KsJTQwlIpjHtPVyjrPiMdrl5AS3y8pb2FBTz40F0

Ashwagandha

"Molecular docking studies have shown that ashwagandha (Withania somnifera) can prevent the novel coronavirus from binding to ACE2 and hence preventing viral entry into host cells along with reducing the expression of TMPRSS2 in certain cells"
https://www.firstpost.com/health/ashwagandha-phytoestrogen-and-other-natural-compounds-can-be-used-to-prevent-manage-covid-19-suggests-study-9026181.html

"The natural compounds from Ashwagandha and Propolis have the potential to be an effective novel coronavirus preventive drug, according to the research team.

"The researchers targeted the main SARS-CoV-2's enzyme for splitting proteins, known as the main protease (Mpro), that plays a key role in mediating viral replication. This is an attractive drug target for this virus, and as humans don't naturally have this enzyme, compounds that target Mpro are likely to have low toxicity," said D Sundar, head of the Delhi Indian Institute of Technology's Biotechnology department"
https://health.economictimes.indiatimes.com/news/diagnostics/ashwagandha-can-be-effective-covid-19-preventive-drug-finds-research-by-iit-delhi-and-japans-aist/75820118

Glycyrrhizin

"GLR has shown activities against different viruses, including SARS-associated Human and animal coronaviruses"
https://pubmed.ncbi.nlm.nih.gov/32592716/

"Glycyrrhizin (GZ) is a promising agent against SARS‐CoV‐2 as its antiviral activity against SARS‐CoV has already been confirmed. It is worthwhile to extrapolate from its proven therapeutic effects as there is a high similarity in the structure and genome of SARS‐CoV and SARS‐CoV‐2. There are many possible mechanisms through which GZ acts against viruses:"
https://onlinelibrary.wiley.com/doi/10.1002/ptr.6852

"Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus."
https://pubmed.ncbi.nlm.nih.gov/12814717/

Luteolin

"Luteolin has been reported to exert inhibitory effects on dengue virus, Epstein-Barr virus (EBV), Japanese encephalitis virus, hepatitis B virus, and hepatitis C virus [10,11,12,13,14]. The mechanisms of these inhibitory effects include activation of extracellular signal-regulated kinase, downregulation of hepatocyte nuclear factor 4, inhibition of the host proprotein convertase furin, and repression of the EBV-induced promotion of immediate-early genes"
https://virologyj.biomedcentral.com/articles/10.1186/s12985-020-01451-6

L-carnitine

"Acyl-Carnitine in pharmaceutical formulations provides therapeutic and preventive antiviral action against HSV, CMV, VZV, HIV and others."
https://www.freepatentsonline.com/5314689.html

Spirulina

"Spirulina helps to penetrate and break down shells of viruses, including coronaviruses."
https://www.energybits.com/blog/fight-the-coronavirus-with-chlorella-spirulina-algae/

"does it work? When attacking a cell, a virus first attaches itself to the cell membrane. However, because of Spirulina extract, the virus cannot penetrate the cell membrane to infect the cell. The virus is stuck, unable to replicate. It is eventually eliminated by the body's natural defenses."
https://inspiredliving.com/greenfoods/a~spirulina-immunesystem.htm

Baicalin

"Baicalin, the main metabolic component of Scutellaria baicalensis Georgi, has various pharmacological properties including anti-inflammatory, anti-oxidant, anti-apoptotic, anti-bactericidal and anti-viral."
https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-020-02595-x

Melatonin

"Melatonin usage was observed to lower the chance of a positive coronavirus test, after adjusting for age, sex, race, smoking history and various disease comorbidities, by about 28%. Even compared with drugs targeting the angiotensin receptor, melatonin usage seemed to significantly reduce the likelihood of a positive test.

The study looked at different patient subgroups and found melatonin usage associated with a 52% reduced likelihood of a positive result for Black patients."
https://www.usatoday.com/story/news/factcheck/2020/11/24/fact-check-melatonin-could-help-against-covid-19-studies-needed/3768894001/

"The hormone, which regulates the body’s circadian rhythm and sleep-wake cycle, was associated with a 30% reduced likelihood of testing positive for COVID-19. However, additional studies are needed, the researchers said.

“It is very important to note these findings do not suggest people should start to take melatonin without consulting their physician,” Feixiong Cheng, the lead author of the study and a researcher in the Cleveland Clinic’s Genomic Medicine Institute, said in a statement."
https://www.webmd.com/lung/news/20201111/melatonin-could-potentially-treat-covid-19

"In the same statement, Dr. Conley added that the president was also taking zinc, vitamin D, famotidine, melatonin, and a daily aspirin."
https://www.health.com/condition/infectious-diseases/coronavirus/donald-trump-covid-19-treatment-medications

Black Pepper

"A few of the science-backed health benefits of black pepper include:

Anti-inflammatory properties
Improved brain function
High levels of antioxidants
Improved blood sugar control

One of the most impressive benefits of black pepper, however, is its ability to boost the bioavailability of essential nutrients that may not be absorbed into the body on their own."
https://rightful.com/beyond-relief/black-pepper-bioavailability/

Antibiotics for possible co-infections

"Overall, 7% of hospitalised COVID-19 patients had a bacterial co-infection (95% CI 3-12%, n=2183, I2=92·2%). A higher proportion of ICU patients had bacterial co-infections than patients in mixed ward/ICU settings (14%, 95% CI 5-26, I2=74·7% versus 4%, 95% CI 1-9, I2= 91·7%)."
https://pubmed.ncbi.nlm.nih.gov/32473235/

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