One of my favorite variants, as both writer and audience are the "familiar environment turned lethal" locations. I think that's a big part of the appeal of subgenres like disaster adventure, post-collapse adventure, and weird survival horror.

You take a place like a quiet suburban street that should be safe and load it down with traps and monsters--human or otherwise. There is a particularly surreal horror to the battle in the mall in Dawn Of The Dead or wandering the mist shrouded streets of Silent Hill.

That's one of the central motifs in my series The Book Of Lost Doors, that exotic and dangerous places can be lurking anywhere, behind boarded up storefronts and down blind alleys.