Hey it's your source.

but seriously I think they are saying 1g per thousand so by weight of fructose in the food/drink. They don't clearly say it in the interview but we know that they explicitly say that half a can of soda will put you over the limit. I'd assume they understand their own results.

a 12 oz can of coke has 39 grams of sugar. If we assume that is regular sugar it will break down to about 19.5g of fructose. A 12 floz soda weighs about 390g so the fructose would come in about 5% by weight. That is still within the same order of magnitude so it seems right just as a check.

I found this (https://f1000.com/prime/732607607) from that same study which says

...shows that the primary site of metabolism is the intestine, but that this is saturable above 0.5g/kg in mice, or they project about a 3g fructose dose in humans.

They quote 3g of fructose in humans to put it over the limit which is less than our 1/2 can of soda (10G fructose) but still on the same order. I also assumed a 12fl oz can where no specific size was specified (could have been 7.5fl oz).

The 3g limit is a good number to have, basically I think it means that you shouldn't consume more than 6g of sugar in a sitting (50% fructose) if you want to keep it out of your liver (good to know!). They also say that eating other foods offers a protective effect because it slows down how fast the fructose hits the small intestine so it can get more of it before it hits the liver

I'd agree with you that it isn't the drug it is the dose. Alcohol is clearly a toxin but I enjoy taking it in and there are health benefits to moderate consumption. The problem is that we consume much more sugar than we ever have before (on average), the change occurring even in the last 30 years. Most of that is hidden... on average (I seem to recall) maybe 1/3 from sugary drinks and 1/6 from deserts/treats but around 50% is just mixed into our food (tomato sauce, yogurt, peanut butter, fast food etc).

This has turned into a pretty fruitful discussion (if anyone else has stuck around for it!). Understanding that some of the fructose gets dealt with by the intestine and we need to limit single sitting level doses to around 3g before it starts most (all?) of the negative health effects is good to know. (also dilute it with lots of other food). Of course further studies pending and they just gave us estimates based on what they saw in mice.