It's a state of mind, many humans are looking for help in self-destructive process it's the natural purpose of sadness, warning signs to a friend are the easiest and more sure to detect.

To not confound with personality traits or hard-truth side-effect, theses two often induce a long term true happiness.

I had a friend who was in such a state of mind, I told him what I was thinking about his situation without fearing his reaction and without over-speaking. I think he appreciated simplicity and honesty.

Staying simple and free, viewing things from above are powerful keys.