Smaller... In pubmed there are many studies not in humans, but in experimental animals. You can find studies like this: "Recombinant FIP-gat, a Fungal Immunomodulatory Protein from Ganoderma atrum, Induces Growth Inhibition and Cell Death in Breast Cancer Cells" (https://www.ncbi.nlm.nih.gov/pubmed/26996414). Experiences in humans can be found on blogs like this (https://healingreishi.wordpress.com/reishi-brain-tumours/) that comment on the reduction of a tumor from 5 cm to 1 cm. Also in pets, I personally know the case of a dog that suffered from bladder cancer and that her veterinarian noticed a reduction in his tumor. The most notorious improvement in this case was that the dog bled every time he pee and from the first month of taking Ganoderma he stopped bleeding.