Thanks for sharing. Yeah, he was pretty amazing and insightful. It seems like a lot of artists from his era were. And those eyes...

the unusual appearance of Bowie’s eyes were due to a condition called anisocoria. Anisocoria is a condition characterised by an unequal size in a person’s pupils. In Bowie’s case, his left pupil was permanently dilated.
This can create the illusion of having different coloured eyes because the fixed pupil does not respond to changes in light, while the right pupil does. So Bowie’s left eye often appeared to be quite dark, due to the blackness of his dilated pupil, when compared to the blue of his right iris.
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So what happened?

Anecdotally, the cause of Bowie’s anisocoria was attributed to the fallout from a lusty scrap in the spring of 1962. Bowie had come to blows with a friend, George Underwood, over a girl they were both hoping to date.
Both were just 15 at the time and their friendship seemingly remained intact. The two performed together in various bands before Underwood turned from music to painting and graphics. But Bowie’s left eye remained seriously damaged.
An impulsive punch had accidentally scratched the eyeball, resulting in paralysis of the muscles that contract the iris. From that day, Bowie’s left pupil remained in a fixed open position.
Over time, Bowie apparently thanked his friend for his notorious eye injury, telling Underwood that it gave him “a kind of mystique”. This mystique helped fuel some of Bowie’s greatest creations and enhance iconic images, such as the album cover for Heroes (1977).
His eyes could appear eerie and mismatched, producing a captivating or mesmeric gaze from on stage or through the lens of a camera. And the uncanny appearance of Bowie’s eyes was ideal for a performer who embraced ideas of the alien, the outsider, the otherworldly and the occult.

From https://theconversation.com/the-remarkable-story-behind-david-bowies-most-iconic-feature-52920