I have this weird relationship with that particular chemical. (I'm the only one know that has 'this'!)

....Alcohol- and any other narcotic that you can think of (of which I've taken copious amounts of, trust me, in my younger days), was no issue, and could party on with the best of them.

1 decent spliff? - I'm comatose in the corner, dribbling.

That was thirty years ago - and my tolerance has never increased.
(even when I was growing the shit and tried 'increasing my tolerance' - all to no avail).

It used to annoy me, tbh - But now I'm older, and not partying hard anymore - I'm more than happy with the situation!