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RE: TODAY in HISTORY (1 October): Alexander the Great conquered the Persian Empire in 331 BC!
I am not very good with ancient history, but I think that the Persian Empire was re-established soon afterwards and was never defeated completely again.
There were other Persian Empires, but not the Medo-Persian Empire which was founded by Cyrus the Great. To distinguish it from the other Persian Empires, it is referred to as the Achaemenid Empire - called after an ancestor of Cyrus, Achaemenes.
The Seleucid Empire, which was the Persian Empire after the Achaemenid Empire, was a division of Alexander's Empire after his death - it was part of what we loosely refer to as the Greek Empire.