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Hi @vinamra. Thank you for your interest. There seems to be no one reason for POTS. If you visit any of the POTS support websites like http://www.potsuk.org/ or https://myheart.net/pots-syndrome/causes-of-pots/ they will give you multiple causes. Primary POTS seems mostly to affect young women, but secondary POTS can come on at any age.

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