A few examples here

HPV Adverse Reactions

Babies screaming for long periods
You should always be on guard that a migraine may be a warning sign of a CBS Gene mutation, especially CBS 699t. When sulfur is not properly metabolized, EXCRUCIATING HEAD PRESSURE may result when sulfites enter the brain and produce acute pain.

Having genetic mutations should be taken into consideration when vaccinating because people that have these genetic mutations are more susceptible to illness

MTHFR gene mutation
Transsulfuration (such as CBS 699t),
Glutathione production and utilization (such as GSTM1), and
Pathogen Load (such as HLA-DR15).
C282Y gene

When gene mutations are present, low cycle output may result in a cascade of debilitating or life threatening events.

http://sanevax.org/four-year-analysis-adverse-reactions-gardasil-hpv-vaccine/