My friend, I think the key is not to self-medicate and take these medications only when necessary. In my country there is this problem, where people without medical consultation, and by a simple pain of the big toe take ibuprofen. They are over-the-counter and I think there is the risk.
I am of the idea of not taking medicines. Only take them when it is really necessary. Really necessary.
Thank you for sharing all this information, as it is always helpful. I hope you have an excellent weekend my friend!