Lose weight without dieting

University of Texas can fulfill the dream of all those who suffer from being overweight - lose weight without going on a diet. They developed a drug that de-metabolizes metabolism and accelerates metabolism.
Lipocytes, fat cells, increase in size, they trigger the overexpression of the protein NNMT. This protein acts as a metabolic brake, which slows down the metabolism, so that the more of them, the more difficult it is for the cells to burn fat - a vicious circle appears. A new experimental drug blocks the action of NNMT in white fat cells, accelerating the metabolic process.

Course of the experiment, mice fattened after a diet high in fat received a drug or a placebo. After 10 days, the first group had a weight loss of 7%, plus the weight of white fat and the size of the lipocytes decreased by 30% compared to the control. In addition, the drug lowered their blood cholesterol levels to normal, even though they continued to eat fatty foods, from which the mice in the placebo group continued to gain weight.

"Blocking the action of the" brake "is an innovative method of increasing the metabolism of cells and reducing the size of the deposits of white fat, affecting the cause of obesity and associated metabolic diseases," said the study's chief author, Harshini Nilakantan.