Yes, this will pay you out in the short run. But if you aren't continuing to upgrade your other buildings you will soon be producing not enough to gain much a reward from daily production bonus or the heist. Since people will continue to progress in the game. If the tip is to start off with the big pharma upgrade off the bat then go from there, being it will give you the best ROI fine. But suggesting to just do that and put all your drugs into the heist this isn't a great strategy at all.