Drug Safety Guide:

I think the best way to start off this guide would be by quoting Erowid "Know your Body. Know your Mind. Know your Substance. Know your Source." and working my way around those 4 rules.

• Know Your Body

By this know of how much your body is capable of. Always follow the recommended dosage per kg of weight for example MDMA safe dosage would be 1.5mg/Kg body mass followed by .5mg/Kg body mass at 1.5-2 hours following.

Never share paraphernalia (e.g. snorting tubes) or especially needles, syringes etc. 

Always try to preform allergic reaction test (Consume a very small amount of the drug and wait at least 30 minutes, If there is any swelling, itching, rash, vomiting your safest bet is to avoid the drug)

Be extremely careful if you have any heart or any other organ conditions, always check if there are any precautions

Stay hydrated, but don't drink too much 100oz is the safe you should consume during the night

• Know Your Mind

Never use drugs or any psychoactive substances as a form of escape from reality. This often leads to addiction and mental illness as by getting high you don't get rid of your problems, you just push them away and because of that they only keep growing.

Be extremely careful while having the addictive personality type as well as any other mental disorders.

Never give in to peer pressure, drug use is your choice and should never be forced onto anyone. 

Trip sitter (A sober person accompanying you) is always a good idea especially with psychedelics.

Use drugs with people you trust in a safe environment

• Know Your Substance

Always test your drugs, i cannot stress how important this is drug testing kits are cheap and can potentially save your life, you can find them everywhere for example here http://testkitplus.com

Research the substance before ingesting it, use websites like erowid.org, psychonautwiki.org you can find there information regarding recommended dosage, lists of subjective effects and trip reports

If on medication, always check if there are any potentially dangerous interactions e.g. SSRI with MDMA

Before combining any drugs check how they interact with each other, Tripsit sheet is incredibly useful:

Higher res: http://wiki.tripsit.me/wiki/Drug_combinations

• Know Your Source

Always get your drugs from a reliable source. Test them before ingestion, if you've been sold different drug for example 25i-nBome instead of LSD, avoid that source at all costs.

 Weigh the product to see if you're not getting ripped off.