Big chance if you get rid of your survival instinct your life changes.

If you want to kill yourself you do it and survival instinct is no longer an issue.
Do you have a reason to be depressed?
Are you active, someone kicking your ass and you have to do hard labour work daily no matter how tired or shit you feel?

Or do you have the luxury to do nothing because you feel so depressed and you have at least 1001 reasons to be?

Or is it in your dna and it attacks you by surprise at moments you feel happy?

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