There are naitive Ledger Nano S apps for BTC, XRP and some others in the google app store.

For ETH and ETC20 tokens I would recommend to use MyEtherWallet together with Ledger.

The tricky part is to get the browser support settings on Ledger to work together with the particular browser. For naitive Google apps (e.g. BTC), I use Chrome and for MEW ETC20 tokens Opera seems to work best. Never got it to work properly on Firefox.

The security on this device is insance, not only do the private keys never leave it (you can even use it on a compromised computer) - but there is are also tests of the firmware integrity everytime the device starts up and for each login through the naitive apps.

Would advice to only use the ledger when there is a need to transfer funds - to check balances, just use the blockchain explorer for whatever coin you have.