Nose Dabs for Brain Cancer

in #cannabis2 years ago

Nose dabbing has made it into the scientific literature for 2020!

Background: Several natural compounds have demonstrated potential for the treatment of central nervous system disorders such as ischemic cerebrovascular disease, glioblastoma, neuropathic pain, neurodegenerative diseases, multiple sclerosis and migraine. This is due to their well-known antioxidant, anti-inflammatory, neuroprotective, anti-tumor, anti-ischemic and analgesic properties. Nevertheless, many of these molecules have poor aqueous solubility, low bioavailability and extensive gastrointestinal and/or hepatic first-pass metabolism, leading to a quick elimination as well as low serum and tissue concentrations. Thus, the intranasal route emerged as a viable alternative to oral or parenteral administration, by enabling a direct transport into the brain through the olfactory and trigeminal nerves. With this approach, the blood-brain barrier is circumvented and peripheral exposure is reduced, thereby minimizing possible adverse effects.

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Objective: Herein, brain-targeting strategies for the nose-to-brain delivery of natural compounds, including flavonoids, cannabinoids, essential oils and terpenes, will be reviewed and discussed. Brain and plasma pharmacokinetics of these molecules will be analyzed and related to their physicochemical characteristics and formulation properties.
Conclusion: Natural compounds constitute relevant alternatives for the treatment of brain diseases but often require loading into nanocarrier systems to reach the central nervous system in sufficient concentrations. Future challenges lie in a deeper characterization of their therapeutic mechanisms and in the development of effective, safe and brain-targeted delivery systems for their intranasal administration.
Keywords: Brain distribution; Central nervous system; Intranasal; Natural compounds; Nose-to-brain; Pharmacokinetics; Phytochemicals.

Source: Bicker, J., Fortuna, A., Alves, G., & Falcão, A. (2020). Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders. Current pharmaceutical design. Advance online publication. doi:10.2174/1381612826666200115101544

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Wow, not only can you bypass the first-pass effect, but you can bypass your lungs altogether, and go straight to the dome! Yes, it's amazing, but do you really have to cry about it? haha ;)

Looks like a good rig for deepthroat dabs, too!

Nah, it's too long, skinny, and curved, haha! We should get a double pronged nose rig for double nose dabs!

Dam, Don't that burn the shit out of your nose? Seems like would make me cry as wll haha

oh yeah it does, haha! Even just doing nose exhales out one side (especially if it's a blocked sinus) and bring tears of joy and pain to my eyes! :-D

Damn.. I would think that would burn your nose hairs

Hahahah, yeaeeah!
I loved it <3

Damn I don’t think I could pull off a nose rip lol

Maybe you'll get the chance to try, sometime.... you can always start small and see if you don't explode! :D

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