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RE: LD50 of Common Materials - You Can Overdose on Everyday Items
When I was looking up LD50s, even though most were done on rats for obvious reasons, Botox came up as the most lethal substance known to man. I think the LD50 was something like a billionth of a gram per kg.
Botox is short for botulinum toxin, so as the name implies, it is a toxic substance. Like a lot of things, though, the dose makes the poison (credit to Paracelcus for this quote BTW, the father of modern toxicology as we know it). Most people are familiar with Botox used for wrinkles, and that is because it works as a neuromuscular deactivator. You can imagine if you gave a large amount of that substance, that once it reaches the heart, lungs, and other required organs, death would be imminent. Apply it strategically, however, and it can be used for many other things. It is used for migraines and neuropathic pain as well.