Each of those psychedelics affects brain chemistry in different ways, dmt usage lsd and psilocyban have action on 5ht2a and 5ht2c receptors though different effects on the sensitization and desensitization of these receptors and their densities. Psylocibans affects on muscarinic nicotinic acid receptors to me are most troublesome compared to the non action of lsd and dmt. All however have the ability to induce nad(p)h oxidase through their activation of 5-ht2a, an enhancement of respiration without satisfaction of breath and proper metabolism. Activation of 5-ht2a and it's subsequent downregulation though is what brings about the positive benefit to psychadelic treatment on disorders such as anxiety and depression deeply rooted in nad(p)+,nad(p)h bioavailability