Electric currents in the axon

in #biology4 years ago (edited)

Perhaps a way to understand electric current in axons is to work backwards. The effect of the nerve impulse must be the high entropy state, work has been performed to get from the resting state to the nerve impulse reaching its destination. The regulator of cell potential energy, ATP, has been metabolically generated to hold the axon nerve impulse system in a low entropy resting state. When it releases that order, the axon becomes incapable of maintaining charge separation, and negative charge moves towards the higher entropy state, electrons flow towards the axon terminal. This collapse towards high entropy (becoming increasingly similar to the dead state), could involve oxidation of reduced calcium stored in the endoplasmic reticulum in the axon cytoplasm, dissolved as Ca2+ . Charge separation no longer being supported by ATP, forces electrons to move towards a state that is supported. Myelin as an insulator limits signal loss, the signal is able to travel further (triggering discharge along the way) before it has to be recharged (the most distal discharge event has to complete .) The low entropy state then has to be recharged, by regeneration of ATP through oxidative phosphorylation.

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