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RE: Sickle Cell Disease: Could Parent's Love Or Ignorance Excuse A Child's Life Time Agony
lovely Pathogenesis/pathophysiology☺☺☺☺
What would you say about Influences of other Variants on Sickling e.g HbF, HbS ad beta Thalassemia?
Thank u. Thanks for reading.
HbF is not really a mutated variant. It is the type that is predominant in intra uterine life and neonatal life, and as a matter of fact is protective against sickling. The basis of giving the patient hydroxyurea is to increase the synthesis of HbF in the Sickle Cell patient.
HbS Beta thalasaemia on the other hand means a person has hemoglobin S in one allele, and beta thalasaemia mutation on the other. Such mutation has been referred to as other variants of sickle cell disease in the article and they usually have mild clinical manifestations, although could often manifest as severe as HbSS and are treated as such.
Thanks Mate. Its better understood.
You are welcome. It will be nice to have you around in @air-clinic, the Healthcare facility on steem. Discord- https://discord.gg/rqded5m
Cheers!