Understanding Correlation measurements of Protein motions from MD trajectories
View this post on Hive: Understanding Correlation measurements of Protein motions from MD trajectories
View this post on Hive: Understanding Correlation measurements of Protein motions from MD trajectories
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Interesting. So where all is correlation mapping used? And are correlation maps result if MD simulations or they are made from wet lab experimental data?
Ok think about a case to see how processes like allostery propagates in a protein or protein protein complex. (Or it can be any bio molecular complex) using correlation maps you can see how the signal propagates. Like we can see how a region interacts with other. Whether it is a repulsive interaction or not. But bare in mind about caveats. It doesn't imply causation.
These maps are usually results of MD simulations. I don't think wet lab experiments can get data with this resolution. And the time scale for averaging to get these maps are of the order of nanoseconds.
Let me know if I answered your questions.
This must be repeated and repeated again and again! Nice generic explanations by the way!
Thank you lemouth for the comment.
Yeah I should be careful to highlight that point regarding correlation. 😃.
You were actually careful, don't worry. I was referring to people in general who are not.
If yall have not seen the book Spurious Correlations ya must.
I know this link, and every time I go there, I have so much fun! Thanks for bringing it back into my memory :)
This is great. I’d consider myself a biochemist and even I learned something here. I was going to ask if these were based on computational calculations or actual measurements, but it looks like @scienceblocks got that answer out of you already :)
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