Amongst psychedelic users there is endless disagreements about this especially talking about LSD (synthetic) versus psilocybin and DMT. This belief shapes the 'set' of users and confirmation bias kicks in, a 'naturalist' is more likely to have a bad trip, in other words, if they are that fixated.

What? Thanks for the info - never heard of this one before. For me I just tried them without expectations.

The real reason for using bio farming methods is not because it necessarily produces a healthier product for us, but because you can rule out inadvertent additions of toxic elements commonly found as contaminants in mineral fertilisers and chemicals like antibiotics in animal production, and in many cases, the biological methods make healthier organisms than chemical ones because of things missing from the more synthetic adjuncts to production.

This is a great explanation, and I also agree that it's better framed just as 'beneficial for life' or 'toxic', although some things swing between these two states, accounting that some people have different biological makeups that'd process things differently.