Yes it is certainly possible, and that's a good reason to check the content before issuing a downvote.

Is it possible to have multiple pieces of content in trending with no comments? Less so without something being not quite right in my opinion.

Personally, I think we should look at Trending from the eyes of a visitor to the site. If they are looking at suspect content which has no commentary, how are they going to feel?

Wow look! I can and get paid this much and I don't even have to respond to anyone #oldsteem