Neurogenesis, Neuroprotectants and Synaptogenesis

Many people believe that once you have all your Brain Cells, that's it, and from there on all you can do is lose them. But that is actually not true. The recent discovery of Neurogenesis shows us that new Brain Cells (Neurons) can be formed in the Human brain, and the discovery of Synaptogenesis shows that new pathways can be created between those Neurons. The difference between these things is that Neurons are the actual Brain Cell, while Synapses are the electrochemical signals of the Neuron. When you hear a song and it reminds you of what you were doing the first time you heard that song, this is called Cognition. Cogs are the gears in a machine, so Cognition can be pictures as gears in a machine, where one gear is attached to something that makes it spin, but the other gears spin because the first gear is spinning them, and that can cause a whole cluster of gears to spin. That is Cognition in your brain also, the first spark causes a series of other sparks, and as in the example you hear a song and remember what you were doing the first time you heard it. This happens along a pathway of Neurons via their Synaptic signaling, the Synapses create the pathways, so with Neurogenesis you have more Neurons and with Synaptogenesis you can create new pathways.

In your brain you have an Endocannabinoid System (ECS), and it has shown to play an important role in different Neural functions. These papers explain some of the things the ECS plays a role in, including Neurogensis

http://link.springer.com/chapter/10.1007%2F978-0-387-74349-3_12

http://www.jci.org/articles/view/25509

This paper includes a full explanation of what Neurogenesis is

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106107/

It has also been shown that the Endocannabinoid called 2-AG has been proven to be able to protect the brain from brain damage in the case of a Traumatic Brain Injury and can stop brain swelling.

This study was done in 2001 and shows that it protects the brain from brain damage

http://www.ncbi.nlm.nih.gov/pubmed/11586361

This study was done in 2003 and shows that it can reverse brain swelling (Edema) which happens to people in a Coma and is  a major cause of death in a Coma, or after a Stroke.

http://www.ncbi.nlm.nih.gov/pubmed/14753451

This study also shows that is can reverse brain swelling

http://www.ncbi.nlm.nih.gov/pubmed/15729296

There is even a Patent for 2-AG that says what it does

https://www.google.com/patents/WO2001097793A2?cl=en

And somehow this information has not made it in to a single Hospital. Even in Colorado where Cannabinoid research is easier and more people have access to it, the Hospitals have no idea what to use it for, and do not have any form of it available. Cannabis in Colorado is all done through Dispensaries and Doctors who specifically have an office for Marijuana patients and not one that has all this research available and materials ready, but usually just an Office where they give Marijuana prescriptions and do check ups if the person wants to come in and see how Marijuana has helped half way through their first year of Prescription. These Doctors aren't specifically affiliated with the Dispensaries,  but they are not in Hospitals either. And none of this kind of information is getting in to the Hospitals. And it is the same all over the country in Medical states, they know that it is good for Chronic Pain, Seizures, Glaucoma, and in place of Opioids. But there aren't Doctors in Hospitals that have patients with Brain Swelling that just say "Let's put some 2-AG in an IV" and there is no 2-AG in the Hospitals when someone has, for example, Traumatic Bain Injury.

These research papers explain how Cannabinoids act as a Neuroprotectant

http://www.ncbi.nlm.nih.gov/pubmed/15837565

http://science.sciencemag.org/content/302/5642/84

Synaptogenesis is connected to Neurogenesis in Cognition, but they are 2 completely different things. Synaptogenesis has to do with Dendrites. Dendrites are arms that extend from your  Neurons and allow the electrochemically signaling between cells. Synaptogenesis is achieved using Ampakines.

This Paper explains how Ampakines create new pathways within hours, and how Ampakines could eventually replace MAOIs and SSRIs.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622786/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195863/

This is also not well known in Hospitals. In Hospitals the Ampakine called Ketamine is used almost like an Opioid alternative. But Ampakines can be used to help create new pathways between Neurons.

Examples of Ampakines include: CX-614, Aniracetam and MXP

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