Scientists make a major breakthrough to treat fibrotic diseases that cause organ failure

Scientists make a major breakthrough to treat fibrotic diseases that cause organ failure

By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers from Duke-NUS Medical School (Duke-NUS) and the National Heart Centre Singapore (NHCS) have discovered that a critical protein, known as interleukin 11 (IL11) is responsible for fibrosis and causes organ damage. While it is surprising that the importance of IL11 has been overlooked and misunderstood for so long, it has now been very clearly demonstrated by this work.

A protein known as transforming growth factor beta 12 (“TGFB1”) has long been known as the major cause of fibrosis and scarring of body organs, but treatments based on switching off the protein have severe side effects. The scientists discovered that IL11, is even more important than TGFB1 for fibrosis and that IL11 is a much better drug target than TGFB1.

Fibrosis is the formation of excessive connective tissue, causing scarring and failure of bodily organs and the skin. …

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(2017-12-02), Scientists make a major breakthrough to treat fibrotic diseases that cause organ failure, Obesity, Fitness & Wellness Week, 3250, ISSN: 1532-4664, BUTTER® ID: 014746330