Russian chemists discovered a surprising effect of a well-known leukemia drug

Russian chemists discovered a surprising effect of a well-known leukemia drug

By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers from RUDN University and Institute of Biomedical Chemistry of the Russian Academy of Sciences have identified an alternative mechanism for the effective antitumor drug -- an enzyme called L-asparaginase. Some isoenzymes of L-asparaginase block the growth of telomeres (region of repetitive nucleotide sequences at each end of a chromosome) on DNA molecules, and this limits the number of divisions of a cancer cell. This effect is reported in the Biochemical and Biophysical Research Communications.

“L-asparaginase enzyme has been used for the treatment of acute lymphoblastic leukemia (cancer of the hematopoietic system) in children for more than 35 years. In recent years, data on its effectiveness in NK/T-cell lymphomas (atype of skin cancer) have been published. We performed a meta-analysis of explored these findings in one of our recent articles”-- said one of the authors of the paper, Vadim Pokrovsky, professor of …

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(2017-12-02), Russian chemists discovered a surprising effect of a well-known leukemia drug, Obesity, Fitness & Wellness Week, 3243, ISSN: 1532-4664, BUTTER® ID: 014746324