Weedle has the lowest base stat total of all Poison-type Pokémon.
In addition, Weedle is tied with five other Pokémon for having the lowest Special Defense stat of all Pokémon, and has the lowest Special Defense of both Poison-type and Bug-type Pokémon.
Until Platinum, Weedle was completely incapable of dealing damage to Steel-type Pokémon—outside of Struggle—because it could only learn Poison Sting, to which Steel types are immune. From Platinum onward, Weedle can learn Bug Bite.
An early design of Weedle's sprite was shown on Game Freak's official Japanese website.
Prior to Generation VI, Weedle's body style was .
Weedle was the inspiration for the naming of Stentorceps weedlei, a species of wasps. Both Weedle and Stentorceps weedlei exhibit the distinctive feature of having a spine in the middle of the organism's head.
Weedle is the only Pokémon that cannot legitimately know any Normal-type moves.
