- Metapod shares its category name with Kakuna, Silcoon, and Cascoon. They are all known as the Cocoon Pokémon.
- They also share the same base stat total, learnset, Ability, and EV yield.
- This ties them as the evolved Pokémon with the lowest base stat total.
- Metapod is the first Pokémon to evolve in a movie, and part of the first evolution cycle in an episode.
- Until the release of Pokémon Platinum, when its pre-evolution became able to learn Bug Bite, Metapod was unable to damage Ghost-type Pokémon except by using Struggle. It shared this trait with Caterpie.
- Due to this, it was impossible to complete a Generation I game using only Caterpie or Metapod since Struggle could not hit Ghost types at the time.
- Metapod is usually depicted with white sclerae, such as in the games, trading cards, and promotional illustrations, but it has yellow sclerae in the anime.
- In the anime episode Challenge of the Samurai, the process of Metapod's evolution was similar to a real life butterfly emerging from its cocoon. In later episodes, however, Metapod is shown to evolve like any other Pokémon.
- Ume Aoki, a Japanese cartoonist famous for her work on the manga Hidamari Sketch, utilizes a likeness of herself cosplaying as a Metapod to represent herself in her works.
