Brain disease is one of the deadly diseases. Especially when this can be said not many effective treatments for this one disease. However, recently, researchers began to make an implant solution to deliver the drug to the brain by remote control and high precision. This implant is very small, even almost equal to the size of the hair.

So, the implants have just been tested on animals. If the device is successful, then this is one new approach to treat brain diseases that can be deadly.

More effective and better-tolerated pharmacological therapies are needed for neurological disorders. Current treatments often rely on systemic administration, resulting in increased risk of toxicity and adverse effects due to off-target drug distribution. Dagdeviren et al. combined intracranial electroencephalogram (EEG) recording with drug delivery in a miniaturized implantable system called MiNDS. [1]

In this way, the side effects of brain treatment will be minimized. That's because these implants will only target brain circuits that require care, especially those that are difficult to reach.

This treatment is considered stronger and safer for brain disorders, ranging from depression to Parkinson's. The patients, later enough to get drugs from the brain without having to bother through what is called a blood-brain barrier.

Moreover, treatment with pills and medications triggers side effects. That's because these drugs penetrate the entire brain region.

Some doctors try other medical techniques by inserting a medicine tube into the brain. Unfortunately, this method is very risky to infection and is still not accurate. these brain implants can provide a dose adjusted for the disease. In fact, it can be used for more than one drug.

The MIT researchers published their findings in a paper on Wednesday in the journal Science Translational Medicine. The main idea behind their device, called a “miniaturized neural drug delivery system” (MiNDS), is that it can precisely treat specific clusters of neurons without causing side effects. This improves upon previous methods that introduce drugs into the cerebrospinal fluid, which can also cause off-target effects. [2]

According to my analysis "The researchers built two very smooth medicine tubes and put them in stainless steel needles with diameters equal to the size of a human hair". But the needle is made with length adjusted to the need to reach the right location on the brain.

How to insert into the brain,

The needle is inserted into the desired brain circuit through a hole in the skull. The Electrodes that are at the end of the needle will provide feedback. It is used to monitor how the electrical activity of neurons in the targeted brain region changes after being given the drug.

The needle will also be connected to two programmable small pumps to hold the medicine. This pump will be implanted into the skin with a fully implanted system called miniaturized neural drug delivery system (MiNDS). This pump can certainly be refilled with injections, and if needed can carry two drugs, similar to printer ink cartridges.

Tested on animals

Currently, these new implants are tested on animals. One of them in mice.
The findings are published in the journal Science Translational Medicine is also tested on other animals, namely monkey.

Scientists at Massachusetts Institute of Technology have developed a radical new way to treat neurodegenerative disorders like Parkinson’s disease, and it sounds pretty freaking sci-fi. Their procedure involves implanting a thin probe connected to a tiny pump into a patient’s brain that delivers precisely measured and targeted drugs to specific brain areas. While this brain implant pump is a long way off from being installed in human patients, it has shown promise in an initial study in laboratory animals, treating Parkinson’s-like symptoms in lab rats and monkeys. [3]

As a result, giving chemicals to different regions alters how targeted brain cells become active. There are even many of groups who are working on implants to deliver neurological medicine in different ways. He also said that additional testing needs to be done before the implant is attempted to humans. because to find a solution and overcome every disease need to do a more details research

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REFERENCE

EndNote:

1. More effective and better-tolerated pharmacological therapiessource
2. Miniaturized neural drug delivery system source
3. Minds-drug-delivery-parkinson source

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