Meanwhile Lucy's symptoms get worse, she looks extremely pale, she is extremely weak and has two small holes in her neck, which Mina thinks she caused them with a pin (the night she found her in the cemetery) when holding her scarf so that his illness does not get worse. Since Lucy's condition is getting worse every day, her fiancé Lord Arthur Holmwood (Lord Godalming) and her friend Quincey Morris, seek advice from Dr. John Seward, who is the director of a mental hospital where a patient is confined. zoophagous Renfield, also under the influence of Count Dracula.

When not seeing any type of improvement in Lucy, Dr. Seward pieda helps his professor Dr. Abraham Van Helsing, a Dutch doctor with many years of experience. He goes to the call of his friend, he takes great affection for Lucy, but despite the efforts of all, the many treatments and blood transfusions, the young woman dies. Days later, curious facts occur that make Dr. Van Helsing think that Lucy has become a "No-Dead" under the influence of Dracula, and she is the cause of the news that the press reports.

After many efforts convinces the three friends and together they go at midnight to the tomb of Lucy, as they run the lid of the urn they realize that her body is not there, and then they watch her turned into a "No-Dead" "With a child in his arms who is drinking his blood. Horrified they decide to return during the day to kill the monster.

After their wedding, Mina and Jonathan return to London, and one afternoon they discover that the count is also there, so the young man gives a diary to his wife in which he wrote daily during his stay in Transylvania. This one is dismayed and, as if that were not enough, a telegram from Van Helsing informs him in detail about the death of his friend. When exchanging some letters, Mina decides to share to the doctor the restlessness of the mental state of her husband and the experiences of this one in the castle of Dracula, with which this one confirms his suspicion: The count is a vampire, and it is necessary to give death him.

Once informed Arthur, Quincey, Seward and Harker join the efforts of Van Helsing to kill Dracula. First try to finish him in London, seeking and purifying their shelters with consecrated hosts, but at the same time the monster convinces Renfield to allow him to enter the sanatorium, where friends had believed to keep Mina out of danger.

Taking advantage of the absence of men, Mina enters and makes a new victim, and Renfield decides to fight against "his master", but Dracula murders him and bites Mina again, but this time makes her drink of his blood to link her to him. Soon after, the friends face the count and can not defeat the mortals flees to his castle.

Mina and Van Helsing make the journey by car to the castle, following the route that at the beginning of the story crossed Jonathan. During the night the three vampires appear before them and Van Helsing manages to drive them away with a host. At dawn the doctor enters the castle, leaving Mina protected with hosts and other amulets, and sticks a stake into the hearts of the three precious women.

Near the sunset the count was approaching his castle, in his coffin guarded by gypsies. At that moment the friends meet and they fight a battle that Jonathan puts an end to when he crosses his dagger in Jonathan's neck while Morris goes through the vampire's heart just before the sun rises forever ending with him and the spell that Weighed on Mina.