One dose of Trodusquemine can reverse heart disease signs

Scientists have discovered a new drug that can dissolve the fat accumulated inside the arteries, which is a "breakthrough" in the fight against heart disease.

The drug has also been effective in breast cancer and diabetes testing, and scientists have now discovered that this drug formulation can promote cardiovascular health.

Scientists tested only one dose of Trudochemine in rats, helping to treat its atherosclerosis, a disease that causes all heart attacks and strokes.

The researchers believe that this drug "simulates" the effects of exercise because it activates the enzyme of prevention, and produces another enzyme that prevents inflammation and atherosclerosis for a long time.

Experts said their findings revealed that the drug had the potential to "dramatically reduce deaths" since heart disease is the leading cause of death worldwide, with 17.7 million deaths annually.

"We know that this drug has shown its beneficial effects on the reduction of long-term infections in type 2 diabetes, and because this disease is also a factor in the disease," said Professor Mirella Dilipigovic of the University of Aberdeen Institute of Medical Sciences, who led the study. Atherosclerosis, we wanted to know whether it has cardiovascular benefits as well. "

Delibegovic said preliminary tests showed the benefits of the drug in rats, stressing the need for further testing and research to see if it has the same effect on humans.

Experts say trudocycin works by stopping an enzyme called PTP1B, which is usually increased in people with obesity or diabetes, as well as in other conditions involving long-term infections such as sepsis or septicemia, foot ulcers and allergic pneumonia .

Previous research has revealed that a deficiency in this enzyme has a protective effect against the formation of atherosclerosis, which prompted the research team to test it on genetically modified mice.

The researchers found that mice who received regular doses of Trudochemine for a long time or even that received a single dose had fatty plaques (accumulating and narrowing of blood vessels) in the arteries, as well as that the drug stimulated the action of the protein "AMPK", which reduces Of chronic inflammation, which plays a key role in all stages of atherosclerosis.